“Diagnosing Inflammation and Infection in the Urinary System via Proteomics”

Journal of Translational Medicine

J Transl Med. 2015 Apr 8;13:111i: 10.1186/s12967-015-0475-3.

Yu Y1, Sikorski, C Bowman-Gholston, Nicolas Cacciabeve MD, Nelson K, Pieper R PhD.

The study using metaproteomic analysis of urine, showed hierarchical clustering of the data revealing that abundances of proteins from activated neutrophils were associated with pathogens in most cases. Proteomic data also allowed assessments of urothelial injury, by quantifying proteins highly expressed in red blood cells and contributing to the acute phase response.